Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4
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چکیده
منابع مشابه
An imported dengue fever case by dengue virus 3 (DENV-3) infection in Gunma, Japan.
Yukio Morita*, Hayato Kogure, Mitsuru Sandoh, Gihei Kawashima, Yoshitake Sato, Sadao Nanba, Yoshihiro Shoda, Tomoyuki Suzuki, Masataka Shiono, Masae Shiobara, Masahiko Kato, Kunihisa Kozawa, Masahiro Noda, Nobuhiko Okabe and Hirokazu Kimura Gunma Prefectural Institute of Public Health and Environmental Sciences; Department of Internal Medicine, General Ota Hospital, Society of Health Insurance ...
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Mature microRNAs (miRNAs) are single-stranded RNAs of 18-24 nucleotides that repress post-transcriptional gene expression. However, it is unknown whether the functions of mature miRNAs can be regulated. Here we report that expression of versican 3'UTR induces organ adhesion in transgenic mice by modulating miR-199a* activities. The study was initiated by the hypothesis that the non-coding 3'UTR...
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Dengue fever (DF) is a mosquito-borne viral disease of great concern in tropical and subtropical regions of the world. One important cause of the increase in DF is rapid development and urbanization has led to proliferation of the Aedes aegypti mosquito, the vector responsible for transmission of the illness. Surveillance of dengue virus (DENV) infection in Brazil shows the predominance of DENV...
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BACKGROUND Dengue virus infection is a growing global public health concern in tropical and subtropical regions of the world. Dengue vaccine development has been hampered by concerns that cross-reactive immunological memory elicited by a candidate vaccine could increase the risk of development of more severe clinical forms. One possible strategy to reduce risks associated with a dengue vaccine ...
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BACKGROUND Delhi, a city in north India, has so far witnessed several reported outbreaks of dengue. Dengue in Delhi from being epidemic is slowly changing towards being endemic and hyper-endemic. Circulating type of the virus is also changing over the years. In the absence of an effective vaccine, dengue prevention to a major extent relies on virological surveillance, and development of effecti...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2008
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2007.11.082